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KMID : 1103920050110010043
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Korean Journal of Hepatology
2005 Volume.11 No. 1 p.43 ~ p.50
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The Prevalence and Clinical Characteristics of Hepatitis-delta Infection in Korea
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정숙향/Jeong SH
김정민/안희준/박명준/백광현/최원/김진/한철주/김유철/이진오/홍영준/박효영/정하현/윤미용/이명진/이기호/Kim JM/Ahn HJ/Park MJ/Paik KH/Choi W/Kim J/Han CJ/Kim YC/Lee JO/Hong YJ/Park HY/Jeong HH/Yoon MY/Lee M/Lee KH
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Abstract
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Background: The prevalence of hepatitis delta virus (HDV) infection has been estimated as being approximately 5% among global HBsAg carriers. The anti-delta positive rate in Koreans had been reported as being 0.85% in 1985. While the prevalence of HBV has been decreased from nearly 10% to 5% during the past twenty years, there have been no more studies on the anti-delta prevalence in Koreans. The aim of this study was to estimate the anti-delta prevalence in Koreans and to study the clinical characteristics of anti-delta positive patients in a single center.
Methods: Serum anti-delta was measured in one hundred ninety four HBsAg-positive patients who were admitted to our hospital from February 2003 to August 2003. We checked the genotypes of the HBV in the anti-delta positive patients. The clinical features of the anti-delta positive patients were compared to those clinical features of the anti-delta negative patients from the aspect of age, gender, mode of transmission, the positivity of HBeAg and serum HBV DNA.
Results: Serum anti-delta was positive in seven patients among the 194 subjects, giving a 3.6% positive rate. Among these seven patients, six had hepatocellular carcinoma (HCC) and the other one had cholangiocarcinoma. All of the anti-delta positive patients had the C genotype of HBV. The anti-delta positive patients showed significantly suppressed HBV DNA replication compared to the anti-delta negative patients.
Conclusions: In Koreans, anti-delta was positive mainly in HCC patients with an approximate prevalence of 4%, and this rate has not changed much for the past twenty years. HBV DNA replication was suppressed by HDV infection.
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